In all of these discourses, she has sought to cultivate an awareness of how the self is situated and influenced, as well as the ways in which a self can influence others.In this volume, twelve scholars examine and display the influence of ...

Ramsey argued that the best way to understand how the theoretical terms of a theory function is to picture them as existentially bound variables. We explore the ontological ramifications of Ramsey's idea by developing a new type of dynamic model-theoretical semantics, based on the concept of an experimental logic.

Clinical ethics consultation is largely outside the scope of regulation and oversight, despite its importance. For decades, the bioethics community has been unable to reach a consensus on whether there should be accountability in this work, as there is for other clinical activities that influence the care of patients. The American Society for Bioethics and Humanities, the primary society of bioethicists and scholars in the medical humanities and the organizational home for individuals who perform CEC in the United States, has (...) initiated a two‐step quality attestation process as a means to assess clinical ethics consultants and help identify individuals who are qualified to perform this role. This article describes the process. (shrink)

We present diverse evidence for the claim of Pullum and Rawlins (2007) that expressives behave differently from descriptives in constructions that enforce a particular kind of semantic identity between elements. Our data are drawn from a wide variety of languages and construction types, and they point uniformly to a basic linguistic distinction between descriptive content and expressive content (Kaplan 1999; Potts 2007).

Research on the use of propranolol as a pharmacological memory dampening treatment for post-traumatic stress disorder is continuing and justifies a second look at the legal and ethical issues raised in the past. We summarize the general ethical and legal issues raised in the literature so far, and we select two for in-depth reconsideration. We address the concern that a traumatized witness may be less effective in a prosecution emerging from the traumatic event after memory dampening treatment. We analyze this (...) issue in relation to sexual assault, where the suggestion that corroborating evidence may remedy any memory defects is less likely to be helpful. We also consider the clinical ethical question about a physician's obligation to discuss potential legal consequences of memory dampening treatment. We conclude that this latter question reflects a general problem related to novel medical treatments where the broader socio-legal consequences may be poorly understood, and suggest that issues of this sort could usefully be addressed through the promulgation of practice guidelines. (shrink)

Although clinical ethics consultation is a high-stakes endeavor with an increasing prominence in health care systems, progress in developing standards for quality is challenging. In this article, we describe the results of a pilot project utilizing portfolios as an evaluation tool. We found that this approach is feasible and resulted in a reasonably wide distribution of scores among the 23 submitted portfolios that we evaluated. We discuss limitations and implications of these results, and suggest that this is a significant step (...) on the pathway to an eventual certification process for clinical ethics consultants. (shrink)

Post-traumatic stress disorder is a “young” disorder formally recognized in the early 1980s, although the symptoms have been noted for centuries particularly in relation to military conflicts. PTSD may develop after a serious traumatic experience that induces feelings of intense fear, helplessness or horror. It is currently characterized by three key classes of symptoms which must cause clinically significant distress or impairment of functioning: persistent and distressing re-experiencing of the trauma; persistent avoidance of stimuli associated with the trauma and numbing (...) of general responsiveness; and persistent symptoms of hyper-arousal. One of the possible symptoms within the second class is difficulty in remembering an important aspect of the traumatic event.PTSD is not an uncommon condition, with an estimated lifetime prevalence of about 7-9% based on studies conducted in the United States and Canada, with women at higher risk than men. While not everyone who experiences a significant trauma will go on to develop PTSD, about a third will do so. Sexual assault, along with other forms of assaultive violence, pose a comparatively high risk of PTSD. (shrink)

In the debate on the ethics of the non-medical use of pharmaceuticals for cognitive performance enhancement in healthy individuals there is a clear division between those who view “cognitive enhancement” as ethically unproblematic and those who see such practices as fraught with ethical problems. Yet another, more subtle issue, relates to the relevance and quality of the contribution of scholarly bioethics to this debate. More specifically, how have various forms of speculation, anticipatory ethics, and methods to predict scientific trends and (...) societal responses augmented or diminished this contribution? In this paper, we use the discussion of the ethics of cognitive enhancement to explore the positive and negative contribution of speculation in bioethics scholarship. First, we review and discuss how speculation has relied on different sets of assumptions regarding the non-medical use of stimulants, namely: terminology and framing; scientific aspects such as efficacy and safety; estimates of prevalence and consequent normalization; and the need for normative reflection and regulatory guidelines. Second, three methodological guideposts are proposed to alleviate some of the pitfalls of speculation: acknowledge assumptions more explicitly and identify the value attributed to assumptions; validate assumptions with interdisciplinary literature; and adopt a broad perspective to promote more comprehensive reflection. We conclude that, through the examination of the controversy about cognitive enhancement, we can employ these methodological guideposts to enhance the value of contributions from bioethics and minimize potential epistemic and practical pitfalls in this case and perhaps in other areas of bioethical debate. (shrink)

While consensus exists among many practitioners of ethics consultation about the need for and identification of core competencies and standards, there has been virtually no attempt to determine how these competencies and standards are best taught and assessed. We believe that clinical ethics consultation has reached a state of sufficient maturity that expert practitioners can evaluate those who are new to the field. We will outline several steps that can facilitate the creation of a certification process for clinical ethics consultants, (...) assuring the competency and quality of consultation for the patients, families, and healthcare professionals who utilize ECSs. (shrink)

Eric Martin and Daniel N. Osherson present a theory of inductive logic built on model theory. Their aim is to extend the mathematics of Formal Learning Theory to a more general setting and to provide a more accurate image of empirical inquiry. The formal results of their study illuminate aspects of scientific inquiry that are not covered by the commonly applied Bayesian approach.

A model of inductive inquiry is defined within the context of first‐order logic. The model conceives of inquiry as a game between Nature and a scientist. To begin the game, a nonlogical vocabulary is agreed upon by the two players, along with a partition of a class of countable structures for that vocabulary. Next, Nature secretly chooses one structure from some cell of the partition. She then presents the scientist with a sequence of facts about the chosen structure. With each (...) new datum the scientist announces a guess about the cell to which the chosen structure belongs. To succeed in his or her inquiry, the scientist’s successive conjectures must be correct all but finitely often, that is, the conjectures must converge in the limit to the correct cell. Different kinds of scientists can be investigated within this framework. At opposite ends of the spectrum are dumb scientists that rely on the strategy of “induction by enumeration,” and smart scientists that rely on an operator of belief revision. We report some results about the scope and limits of these two inductive strategies. (shrink)

Brain reading technologies are rapidly being developed in a number of neuroscience fields. These technologies can record, process, and decode neural signals. This has been described as ‘mind reading technology’ in some instances, especially in popular media. Should the public at large, be concerned about this kind of technology? Can it really read minds? Concerns about mind-reading might include the thought that, in having one’s mind open to view, the possibility for free deliberation, and for self-conception, are eroded where one (...) isn’t at liberty to privately mull things over. Themes including privacy, cognitive liberty, and self-conception and expression appear to be areas of vital ethical concern. Overall, this article explores whether brain reading technologies are really mind reading technologies. If they are, ethical ways to deal with them must be developed. If they are not, researchers and technology developers need to find ways to describe them more accurately, in order to dispel unwarranted concerns and address appropriately those that are warranted. (shrink)

Throughout the biological and biomedical sciences there is a growing need for, prescriptive ‘minimum information’ (MI) checklists specifying the key information to include when reporting experimental results are beginning to find favor with experimentalists, analysts, publishers and funders alike. Such checklists aim to ensure that methods, data, analyses and results are described to a level sufficient to support the unambiguous interpretation, sophisticated search, reanalysis and experimental corroboration and reuse of data sets, facilitating the extraction of maximum value from data sets (...) them. However, such ‘minimum information’ MI checklists are usually developed independently by groups working within representatives of particular biologically- or technologically-delineated domains. Consequently, an overview of the full range of checklists can be difficult to establish without intensive searching, and even tracking thetheir individual evolution of single checklists may be a non-trivial exercise. Checklists are also inevitably partially redundant when measured one against another, and where they overlap is far from straightforward. Furthermore, conflicts in scope and arbitrary decisions on wording and sub-structuring make integration difficult. This presents inhibit their use in combination. Overall, these issues present significant difficulties for the users of checklists, especially those in areas such as systems biology, who routinely combine information from multiple biological domains and technology platforms. To address all of the above, we present MIBBI (Minimum Information for Biological and Biomedical Investigations); a web-based communal resource for such checklists, designed to act as a ‘one-stop shop’ for those exploring the range of extant checklist projects, and to foster collaborative, integrative development and ultimately promote gradual integration of checklists. (shrink)

This paper shows how late 1960’s student protests influenced the thought of Imre Lakatos and Paul Feyerabend. I argue that student movements shaped their work from this period, specifically Lakatos’s “Falsification and the Methodology of Scientific Research Programmes” and Feyerabend’s Against Method. Archival evidence shows that their political environments at London and Berkeley inflected their writing on scientific method, entrenching Lakatos’s search for a rationalist account of scientific development, and encouraging Feyerabend’s ‘anarchistic’ theory of knowledge. I document this influence and (...) draw two broader lessons: one lesson about the role of biography in philosophy and the other about the historiography of student protests. (shrink)

We present a model for first-order belief revision that is characterized by an underlying relevance-like relation and a background proof system. The model is extremely general in order to allow for a wide variety in these characterizing parameters. It allows some weakenings of beliefs which were initially implicit to become explicit and survive the revision process. The effects of revision are localized to the part of the theory that is influenced by the the new information. Iterated revision in this model (...) is handled trivially since the revision operator is constructive by definition. The usage of deductively limited proof systems permits an inconsistency tolerant model. The notion of a part of a theory capable of being influenced by new information (designed to accomodate the specific character of first-order languages) is shown to satisfy some intuitive and desirable properties. We show that for particular parametrizations, standard revision schemes can be embedded into our paradigm. (shrink)

In this consensus report by a diverse group of academics who conduct and/or are concerned about social and behavioral genomics (SBG) research, the authors recount the often‐ugly history of scientific attempts to understand the genetic contributions to human behaviors and social outcomes. They then describe what the current science—including genomewide association studies and polygenic indexes—can and cannot tell us, as well as its risks and potential benefits. They conclude with a discussion of responsible behavior in the context of SBG research. (...) SBG research that compares individuals within a group according to a “sensitive” phenotype requires extra attention to responsible conduct and to responsible communication about the research and its findings. SBG research (1) on sensitive phenotypes that (2) compares two or more groups defined by (a) race, (b) ethnicity, or (c) genetic ancestry (where genetic ancestry could easily be misunderstood as race or ethnicity) requires a compelling justification to be conducted, funded, or published. All authors agree that this justification at least requires a convincing argument that a study's design could yield scientifically valid results; some authors would additionally require the study to have a socially favorable risk‐benefit profile. (shrink)

This paper shows how late 1960’s student protests influenced the thought of Imre Lakatos and Paul Feyerabend. I argue that student movements shaped their work from this period, specifically Lakatos’s “Falsification and the Methodology of Scientific Research Programmes” and Feyerabend’s Against Method. Archival evidence shows that their political environments at London and Berkeley inflected their writing on scientific method, entrenching Lakatos’s search for a rationalist account of scientific development, and encouraging Feyerabend’s ‘anarchistic’ theory of knowledge. I document this influence and (...) draw two broader lessons: one lesson about the role of biography in philosophy and the other about the historiography of student protests. (shrink)

Scientific inquiry is represented as a process of rational hypothesis revision in the face of data. For the concept of rationality, we rely on the theory of belief dynamics as developed in [5, 9]. Among other things, it is shown that if belief states are left unclosed under deductive logic then scientific theories can be expanded in a uniform, consistent fashion that allows inquiry to proceed by any method of hypothesis revision based on "kernel" contraction. In contrast, if belief states (...) are closed under logic, then no such expansion is possible. (shrink)

It is a classical result of Mortimer that $L^2$ , first-order logic with two variables, is decidable for satisfiability. We show that going beyond $L^2$ by adding any one of the following leads to an undecidable logic:– very weak forms of recursion, viz.¶(i) transitive closure operations¶(ii) (restricted) monadic fixed-point operations¶– weak access to cardinalities, through the Härtig (or equicardinality) quantifier¶– a choice construct known as Hilbert's $\epsilon$ -operator.In fact all these extensions of $L^2$ prove to be undecidable both for satisfiability, (...) and for satisfiability in finite structures. Moreover most of them are hard for $\Sigma^1_1$ , the first level of the analytical hierachy, and thus have a much higher degree of undecidability than first-order logic. (shrink)

Scientific inquiry is represented as a process of rational hypothesis revision in the face of data. For the concept of rationality, we rely on the theory of belief dynamics as developed in [5, 9]. Among other things, it is shown that if belief states are left unclosed under deductive logic then scientific theories can be expanded in a uniform, consistent fashion that allows inquiry to proceed by any method of hypothesis revision based on “kernel” contraction. In contrast, if belief states (...) are closed under logic, then no such expansion is possible. (shrink)

A model of inductive inquiry is defined within a first-order context. Intuitively, the model pictures inquiry as a game between Nature and a scientist. To begin the game, a nonlogical vocabulary is agreed upon by the two players along with a partition of a class of structures for that vocabulary. Next, Nature secretly chooses one structure ("the real world") from some cell of the partition. She then presents the scientist with a sequence of atomic facts about the chosen structure. With (...) each new datum the scientist announces a guess about the cell to which the chosen structure belongs. To succeed in his inquiry, the scientist's successive conjectures must be correct all but finitely often, that is, the conjectures must converge in the limit to the correct cell. A special kind of scientist selects his hypotheses on the basis of a belief revision operator. We show that reliance on belief revision allows scientists to solve a wide class of problems. (shrink)

In Minker and Rajasekar (J Log Program 9(1):45–74, 1990), Minker proposed a semantics for negation-free disjunctive logic programs that offers a natural generalisation of the fixed point semantics for definite logic programs. We show that this semantics can be further generalised for disjunctive logic programs with classical negation, in a constructive modal-theoretic framework where rules are built from _claims_ and _hypotheses_, namely, formulas of the form \(\Box \varphi \) and \(\Diamond \Box \varphi \) where \(\varphi \) is a literal, respectively, (...) yielding a “base semantics” for general disjunctive logic programs. Model-theoretically, this base semantics is expressed in terms of a classical notion of logical consequence. It has a complete proof procedure based on a general form of the cut rule. Usually, alternative semantics of logic programs amount to a particular interpretation of nonclassical negation as “failure to derive.” The counterpart in our framework is to complement the original program with a set of hypotheses required to satisfy specific conditions, and apply the base semantics to the resulting set. We demonstrate the approach for the answer set semantics. The proposed framework is purely classical in mainly three ways. First, it uses classical negation as unique form of negation. Second, it advocates the computation of logical consequences rather than of particular models. Third, it makes no reference to a notion of preferred or minimal interpretation. (shrink)

A model of inductive inquiry is defined within the context of first‐order logic. The model conceives of inquiry as a game between Nature and a scientist. To begin the game, a nonlogical vocabulary is agreed upon by the two players, along with a partition of a class of countable structures for that vocabulary. Next, Nature secretly chooses one structure from some cell of the partition. She then presents the scientist with a sequence of facts about the chosen structure. With each (...) new datum the scientist announces a guess about the cell to which the chosen structure belongs. To succeed in his or her inquiry, the scientist’s successive conjectures must be correct all but finitely often, that is, the conjectures must converge in the limit to the correct cell. Different kinds of scientists can be investigated within this framework. At opposite ends of the spectrum are dumb scientists that rely on the strategy of “induction by enumeration,” and smart scientists that rely on an operator of belief revision. We report some results about the scope and limits of these two inductive strategies. (shrink)

Parametric logic is a framework that generalises classical first-order logic. A generalised notion of logical consequence—a form of preferential entailment based on a closed world assumption—is defined as a function of some parameters. A concept of possible knowledge base—the counterpart to the consistent theories of first-order logic—is introduced. The notion of compactness is weakened. The degree of weakening is quantified by a nonnull ordinal—the larger the ordinal, the more significant the weakening. For every possible knowledge base T, a hierarchy of (...) sentences that are generalised logical consequences of T is built. The first layer of the hierarchies corresponds to sentences that can be obtained by a deductive inference, characterised by the compactness property. The second layer of the hierarchies corresponds to sentences that can be obtained by an inductive inference, characterised by the property of weak compactness quantified by 1. Weaker forms of compactness—quantified by nonnull ordinals—determine higher layers in the hierarchies, corresponding to more complex inferences. The naturalness of the hierarchies built over the possible knowledge bases is attested by fundamental connections with notions from Learning theory and from topology. The naturalness of the hierarchies built over the possible knowledge bases is attested by fundamental connections with notions from Learning theory—classification in the limit, with or without a bounded number of mind changes—and from topology—in reference to the Borel and the difference hierarchies. In this paper, we introduce the key model-theoretic aspects of Parametric logic, justify the concept of the knowledge base, define the hierarchies of generalised logical consequences and illustrate their relevance to Nonmonotonic reasoning. More specifically, we show that the degree of nonmonotonicity that is required to infer a sentence can be characterised by the least nonnull ordinal that quantifies the weakening of compactness used to locate the inferred sentence in the hierarchies. (shrink)

The inductive logic developed in the second and third essays is limited in important ways. For example: (a) the logic makes no provision for missing or misleading data; (b) it gives the scientist no control over the evidence reaching him; (c) revision-based scientist must work with theories written in the cramped idiom of firstorder logic; (d) the idea of efficient induction is only weakly expressed (in terms of “dominance”).

This paper reviews the natural philosophies of John Polkinghorne and Nancy Cartwright, with particular emphasis on the role of pluralism in their respective writings. While often motivated by distinct projects, their philosophies display some interesting and perhaps unexpected similarities. It is suggested that Polkinghorne's views are not far away from some of Cartwright's proposals, and further that certain debates about God's providential action could be helpfully reoriented if the insistence on natural laws as a centerpiece of scientific explanation were relinquished.

In the four papers available on our web site (of which this is the first), we propose to develop an inductive logic. By “inductive logic” we mean a set of principles that distinguish between successful and unsuccessful strategies for scientific inquiry. Our logic will have a technical character, since it is built from the concepts and terminology of (elementary) model theory. The reader may therefore wish to know something about the kind of results on offer before investing time in definitions (...) and notation. Providing such an informal overview is the purpose of the present essay. We begin with discussion of the central concept under investigation, namely, theory acceptance. (shrink)

Continuous sedation at the end of life is a practice that has attracted a great deal of attention. An increasing number of guidelines on the proposed correct performance of the practice have been drafted. All of the guidelines stress the importance of using sedation in proportion to the severity of the patient’s symptoms, thus to reduce the patient’s consciousness no more than is absolutely necessary. As different patients can have different experiences of suffering, the amount of suffering should, ideally, be (...) assessed subjectively; that is, via communication with the patient. Continuously sedated patients are often unable to communicate, however, making subjective methods of pain assessment unusable. For these patients, the degree of consciousness is the sole available measure. It therefore seems important to adequately measure how deeply the patient is sedated, thereby allowing sedation to be increased when it is too light and decreased when it is too heavy. This is in accordance with the idea that reducing consciousness is not an ethically neutral act.Although consciousness measuring techniques are a hot topic in anesthesiology, almost no research exists on the use of such techniques in the context of continuous sedation at the end of life. This article aims to review existing techniques to measure consciousness and to evaluate their applicability, efficiency, and invasiveness for patients who are continuously sedated until death.Techniques commonly used to assess the depth of sedation in continuously sedated patients are basic clinical assessment and sedation scales, as they are often considered reliable and noninvasive. These techniques might not be very reliable, however, since it is known that some patients are nonresponsive and yet aware. Moreover, sedation scales require stimulation of the patient (for example prodding, shaking, or providing painful stimuli), and can thus be considered invasive of one’s bodily integrity or dignity. Other techniques, such as EEG (electroencephalography) derivatives, may score better on reliability and invasiveness. Yet these have so far never been compared to sedation scale scores for patients receiving continuous sedation at the end of life.Therefore, we conclude that, for both clinical and ethical reasons, research into the efficiency and applicability of other techniques, such as derivatives of EEG, are urgently needed. (shrink)

Aworkshop was held August 26–28, 2015, by the Earth- Life Science Institute (ELSI) Origins Network (EON, see Appendix I) at the Tokyo Institute of Technology. This meeting gathered a diverse group of around 40 scholars researching the origins of life (OoL) from various perspectives with the intent to find common ground, identify key questions and investigations for progress, and guide EON by suggesting a roadmap of activities. Specific challenges that the attendees were encouraged to address included the following: What key (...) questions, ideas, and investigations should the OoL research community address in the near and long term? How can this community better organize itself and prioritize its efforts? What roles can particular subfields play, and what can ELSI and EON do to facilitate research progress? (See also Appendix II.) The present document is a product of that workshop; a white paper that serves as a record of the discussion that took place and a guide and stimulus to the solution of the most urgent and important issues in the study of the OoL. This paper is not intended to be comprehensive or a balanced representation of the opinions of the entire OoL research community. It is intended to present a number of important position statements that contain many aspirational goals and suggestions as to how progress can be made in understanding the OoL. The key role played in the field by current societies and recurring meetings over the past many decades is fully acknowledged, including the International Society for the Study of the Origin of Life (ISSOL) and its official journal Origins of Life and Evolution of Biospheres, as well as the International Society for Artificial Life (ISAL). (shrink)

Developing countries face numerous barriers to conducting effective and efficient ethics reviews of international collaborative research. In addition to potentially overlooking important scientific and ethical considerations, inadequate or insufficiently trained ethics committees may insist on unwarranted changes to protocols that can impair a study's scientific or ethical validity. Moreover, poorly functioning review systems can impose substantial delays on the commencement of research, which needlessly undermine the development of new interventions for urgent medical needs. In response to these concerns, the Drugs (...) for Neglected Diseases Initiative, an independent nonprofit organization founded by a coalition of public sector and international organizations, developed a mechanism to facilitate more effective and efficient host country ethics review for a study of the use of fexinidazole for the treatment of late stage African Trypanosomiasis. The project involved the implementation of a novel ‘pre-review’ process of ethical oversight, conducted by an ad hoc committee of ethics committee representatives from African and European countries, in collaboration with internationally recognized scientific experts. This article examines the process and outcomes of this collaborative process. (shrink)

We present a framework that provides a logic for science by generalizing the notion of logical (Tarskian) consequence. This framework will introduce hierarchies of logical consequences, the first level of each of which is identified with deduction. We argue for identification of the second level of the hierarchies with inductive inference. The notion of induction presented here has some resonance with Popper's notion of scientific discovery by refutation. Our framework rests on the assumption of a restricted class of structures in (...) contrast to the permissibility of classical first-order logic. We make a distinction between deductive and inductive inference via the notions of compactness and weak compactness. Connections with the arithmetical hierarchy and formal learning theory are explored. For the latter, we argue against the identification of inductive inference with the notion of learnable in the limit. Several results highlighting desirable properties of these hierarchies of generalized logical consequence are also presented. (shrink)

By organizing crowds of scientists to independently tackle the same research questions, we can collectively overcome the generalizability crisis. Strategies to draw inferences from a heterogeneous set of research approaches include aggregation, for instance, meta-analyzing the effect sizes obtained by different investigators, and parsing, attempting to identify theoretically meaningful moderators that explain the variability in results.

Background Implicit biases are present in the general population and among professionals in various domains, where they can lead to discrimination. Many interventions are used to reduce implicit bias. However, uncertainties remain as to their effectiveness. -/- Methods We conducted a systematic review by searching ERIC, PUBMED and PSYCHINFO for peer-reviewed studies conducted on adults between May 2005 and April 2015, testing interventions designed to reduce implicit bias, with results measured using the Implicit Association Test (IAT) or sufficiently similar (...) methods. -/- Results 30 articles were identified as eligible. Some techniques, such as engaging with others’ perspective, appear unfruitful, at least in short term implicit bias reduction, while other techniques, such as exposure to counterstereotypical exemplars, are more promising. Robust data is lacking for many of these interventions. -/- Conclusions Caution is thus advised when it comes to programs aiming at reducing biases. This does not weaken the case for implementing widespread structural and institutional changes that are multiply justified. (shrink)

BackgroundFunctional neurodiagnostics could allow researchers and clinicians to distinguish more accurately between the unresponsive wakefulness syndrome and the minimally conscious state. It remains unclear how it informs surrogate decision-making.ObjectiveTo explore how the next of kin of patients with disorders of consciousness interpret the results of a functional neurodiagnostics measure and how/why their interpretations influence their attitudes towards medical decisions.Methods and SampleWe conducted problem-centered interviews with seven next of kin of patients with DOC who had undergone a functional HD-EEG examination at (...) a neurological rehabilitation center in Germany. The examination included an auditory oddball paradigm and a motor imagery task to detect hidden awareness. We analyzed the interview transcripts using structuring qualitative content analysis.ResultsRegardless of the diagnostic results, all participants were optimistic of the patients’ meaningful recovery. We hypothesize, that participants deal with the results of examinations according to their belief system. Thus, an unfavorable evaluation of the patient’s state had the potential to destabilize the participant’s belief system. To re-stabilize or to prevent the destabilization of their belief system, participants used different strategies. Participants accepted a “positive” HD-EEG result since it stabilized their belief system.ConclusionWe hypothesize, that a group of next of kin of patients with DOC deals with functional neurodiagnostics results on the basis of the result’s value and their high hope that the patient will recover meaningfully. A psychological mechanism seems to moderate the impact of functional neurodiagnostics on surrogate treatment decisions. (shrink)

Summary A provocative examination of the consequences of Levinas’s and Adorno’s thought for contemporary ethics and political philosophy. This book sets up a dialogue between Emmanuel Levinas and Theodor W. Adorno, using their thought to address contemporary environmental and social-political situations. Eric S. Nelson explores the “non-identity thinking” of Adorno and the “ethics of the Other” of Levinas with regard to three areas of concern: the ethical position of nature and “inhuman” material others such as environments and animals; the (...) bonds and tensions between ethics and religion and the formation of the self through the dynamic of violence and liberation expressed in religious discourses; and the problematic uses and limitations of liberal and republican discourses of equality, liberty, tolerance, and their presupposition of the private individual self and autonomous subject. Thinking with and beyond Levinas and Adorno, this work examines the possibility of an anarchic hospitality and solidarity between material others and sensuous embodied life. “This is an extremely impressive, original, and thorough treatment of two key twentieth-century thinkers and their applicability to the most pressing social and political issues of our time.” — Jeffrey A. Bernstein, author of Leo Strauss on the Borders of Judaism, Philosophy, and History “This book is an excellent and timely contribution to political and environmental philosophy, located around a nuanced historical and philosophical approach to Levinas and Adorno. It will be of great interest to anyone concerned with these figures or with the current moment.” — Martin Shuster, author of Autonomy after Auschwitz: Adorno, German Idealism, and Modernity. (shrink)

Reduced Environmental Stimulation Therapy (REST) alters the balance of sensory input to the nervous system by systematically attenuating sensory signals from visual, auditory, thermal, tactile, vestibular, and proprioceptive channels. Previous research from our group has shown that REST via floatation acutely reduces anxiety and blood pressure while simultaneously heightening interoceptive awareness in clinically anxious populations. Anorexia nervosa (AN) is an eating disorder characterized by elevated anxiety, distorted body representation, and abnormal interoception, raising the question of whether REST might positively impact (...) these symptoms. However, this approach has never been studied in eating disorders and it is unknown whether exposure to REST might worsen AN symptoms. To examine these possibilities we conducted an open-label study to investigate the safety and tolerability of REST in AN. We also explored the impact of REST on affective symptoms, body image disturbance, and interoception. Twenty-one partially weight-restored AN outpatients completed a protocol involving four sequential sessions of REST: reclining in a zero-gravity chair, floating in an open pool, and two sessions of floating in an enclosed pool. All sessions were 90 minutes, approximately one week apart. We measured orthostatic blood pressure before and immediately after each session (primary outcome), in addition to collecting blood pressure readings every 10 minutes during the session using a wireless waterproof system as a secondary outcome measure. Each participant's affective state, awareness of interoceptive sensations, and body image was assessed before and after every session (exploratory outcomes). There was no evidence of orthostatic hypotension following floating, and no adverse events (primary outcome). Secondary analyses revealed that REST induced statistically significant reductions in blood pressure, anxiety and negative affect, heightened awareness of cardiorespiratory but not gastrointestinal sensations, and reduced body image dissatisfaction. The findings from this initial trial suggest that individuals with AN can safely tolerate the physical effects of REST via floatation. Future randomized controlled trials will need to investigate whether these initial observations of improved anxiety, interoception, and body image disturbance can be effectively extended to acutely ill AN populations. (shrink)

Autistic disorders are characterized by deficits in social interactions and communication, strong aversion or non-response to social stimuli. However, these children are often reported to develop strong bonds with companion animals. We hypothesized that children with autism would present different behavioural profiles when encountering an unfamiliar animal in aStrange Animal Situationclose-to-life test. Twenty seven CAD were compared to 59 children with typical development. Our results. revealed similarities in the behaviour of both groups of children as well as patterns specific to (...) the CAD. Different profiles emerged depending on everyday living conditions. This study constitutes, to our knowledge, the first clear description of how children with autism react when encountering an unfamiliar animal and one of the first direct comparisons between CAD and CTD using a naturalistic but standardized setting. Keywords: autism; animal; profile; interaction; ethology. (shrink)

Autistic disorders are characterized by deficits in social interactions and communication, strong aversion or non-response to social stimuli. However, these children are often reported to develop strong bonds with companion animals. We hypothesized that children with autism would present different behavioural profiles when encountering an unfamiliar animal in a Strange Animal Situation close-to-life test. Twenty seven CAD were compared to 59 children with typical development. Our results. revealed similarities in the behaviour of both groups of children as well as patterns (...) specific to the CAD. Different profiles emerged depending on everyday living conditions. This study constitutes, to our knowledge, the first clear description of how children with autism react when encountering an unfamiliar animal and one of the first direct comparisons between CAD and CTD using a naturalistic but standardized setting. Keywords: autism; animal; profile; interaction; ethology. (shrink)

This contribution unfolds an existential-ontological response to the question of sexual difference in the context of Heidegger’s formally indicative concept of “Dasein.” The question of Dasein’s “neutrality” concerns how formal indication formalizes, empties, and neutralizes the givenness of factical human existence. Ostensibly “given” biological and anthropological facts, such as sexual difference, are interpreted from an emptied and neutralized perspective that appears abstract and fictional to Heidegger’s critics. How, then, is the “neutrality” of formalizing emptying related to the “facticity” of in (...) each case factically existing as a sexual and gendered being? The answer lies in Heidegger’s elucidation of the existential-ontological structure of Dasein: Dasein is always relationally instituted in its factical entangled life through “being-with.” The sexual difference of human existence is not merely biologically or anthropologically given, but disclosed and enacted according to one’s relations with others, the environment, and oneself. The formally indicating concept “Dasein” indicates, accordingly, the concrete diversity and plurality of individuated sexual and gendered ways of being. (shrink)